“ Inhibitors of the tick - borne , hemorrhagic fever - associated flaviviruses . ” 3 4
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word count: 250 18 Text word count: 5516 19 AAC Accepts, published online ahead of print on 24 March 2014 Antimicrob. Agents Chemother. doi:10.1128/AAC.02393-14 Copyright © 2014, American Society for Microbiology. All Rights Reserved. on July 6, 2017 by gest httpaac.asm .rg/ D ow nladed fom
منابع مشابه
Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy.
Here, we analyze the complete coding sequences of all recognized tick-borne flavivirus species, including Gadgets Gully, Royal Farm and Karshi virus, seabird-associated flaviviruses, Kadam virus and previously uncharacterized isolates of Kyasanur Forest disease virus and Omsk hemorrhagic fever virus. Significant taxonomic improvements are proposed, e.g. the identification of three major groups ...
متن کاملA critical determinant of neurological disease associated with highly pathogenic tick-borne flavivirus in mice.
UNLABELLED Tick-borne encephalitis virus (TBEV) and Omsk hemorrhagic fever virus (OHFV) are highly pathogenic tick-borne flaviviruses; TBEV causes neurological disease in humans, while OHFV causes a disease typically identified with hemorrhagic fever. Although TBEV and OHFV are closely related genetically, the viral determinants responsible for these distinct disease phenotypes have not been id...
متن کاملFlaviviral Infections and Potential Targets for Antiviral Therapy
The family Flaviviridae includes human and animal pathogenic viruses of global importance, e.g. the human flaviviruses West-Nile virus (WNV), dengue virus (DENV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV) and yellow fever virus (JEV) as well as hepacivirus hepatitis C virus (HCV). This virus family was named after the jaundice occurring in course of YFV infection, ...
متن کاملSeroprevalence report on tick-borne encephalitis virus and Crimean-Congo hemorrhagic fever virus among Malaysian’s farm workers
BACKGROUND Tick-borne encephalitis virus (TBEV) and Crimean-Congo haemorrhagic fever virus (CCHFV) are important tick-borne viruses. Despite their wide geographical distribution and ease of acquisition, the prevalence of both viruses in Malaysia is still unknown. This study was conducted to determine the seroprevalence for TBEV and CCHFV among Malaysian farm workers as a high-risk group within ...
متن کاملInhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.
No antiviral therapies are available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). We tested compounds reported to have antiviral activity against members of the Flaviviridae family for their ability to inhibit AHFV replicat...
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